南京大学学报(自然科学版) ›› 2021, Vol. 57 ›› Issue (3): 401–408.doi: 10.13232/j.cnki.jnju.2021.03.007
蛋白冠的形成及其对纳米颗粒生物效应的影响概述
向芷芊, 缪爱军(
)
- 污染控制与资源化研究国家重点实验室，南京大学环境学院，南京，210023
Formation of protein corona and their influence on the biological effects of nanoparticles: A review
Zhiqian Xiang, Aijun Miao()
- State Key Laboratory of Pollution Control and Resource Reuse，School of the Environment, Nanjing University，Nanjing，210023，China
摘要：
纳米颗粒被广泛应用于社会生活的各个领域，其生物效应亟须研究.一旦纳米颗粒与生物体液接触，其表面会迅速吸附一层蛋白质分子（蛋白冠），从而使得纳米颗粒具有了新的生物学特性.不同于体外环境，含有蛋白冠的纳米颗粒才是它们在生物体内的真实状态.纳米颗粒的理化特性（例如粒径、形状、表面修饰等）可以影响蛋白冠的组成.与此同时，外界环境条件（例如培养基组成、培养时间、温度、pH等）也是影响蛋白冠组成的重要因素.蛋白冠的存在会影响纳米颗粒和生物体间的相互作用，改变纳米颗粒的生物吸收、生物分布以及生物毒性.尽管如此，不同蛋白质分子与纳米颗粒表面特异性结合的内在机制目前尚不清楚，同时生物体内蛋白冠?纳米颗粒复合体的动态变化研究手段还较少，这些都是未来需要解决的问题.
中图分类号:
- X171
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