南京大学学报(自然科学版) ›› 2011, Vol. 47 ›› Issue (2): 147154.
齐水宝, 崔炜程, 屠 娟** , 陈伟中
Qi Shui Bao, Cui Wei Cheng, T u J uan, Chen Wei Zhong
摘要: 超声造影剂是由薄膜层包裹气体形成的微米量级的包膜气泡. 随着医学超声技术的发展, 超声造影剂在诊断及治疗超声领域的应用得到了广泛的关注. 超声造影剂的包膜特性(如剪切模量及剪切
粘度)是与其应用紧密相关的重要参数, 对于决定气泡的许多功能特性都是非常重要的. 本文在 Mie 散射理论基础上, 利用进过改进的流式细胞仪测量了单个 Definity
超声造影剂微泡的动力学行为, 并对其包膜特性进行了分析. 通过对实验测量得到的微泡动力学响应数据进行气泡动力学拟合来可以确定
不同驱动声压(95- 333 kPa 之间) 下造影剂微泡的包膜特性. 结果显示: 造影剂微泡包膜的剪切粘度随微泡平衡半径的增大而增大, 随剪切速率的增大而减小; 而包膜的弹性系数不随微泡的大小而变化.
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