HMGB3在乳腺癌中的预后和功能：基于生物信息学分析

王文艺, 徐佳玮, 顾军

The prognosis and function of HMGB3 in breast cancer: Based on bioinformatics analysis

Wenyi Wang, Jiawei Xu, Jun Gu

表2 HMGB3及其共表达基因的功能注释分析

Table 2 Functional annotation analysis of HMGB3 and its co?expressed genes

subtype functional annotation FDR genes Biological process DNA metabolic process 1.50e-05 HMGB2，KIAA0101，RRM2，DKC1， HMGB3，ORC1，POLA1，DUT，RFC5 DNA replication 1.56e-05 KIAA0101，RRM2，ORC1，POLA1，DUT，RFC5 DNA biosynthetic process 0.00071 KIAA0101，DKC1，POLA1，RFC5 regulation of transcription involved in G1/S transition of mitotic cell cycle 0.00089 RRM2，ORC1，POLA1 mitotic cell cycle phase transition 0.00089 CCNB1，UBE2C，RRM2，ORC1，POLA1 cell cycle process 0.0017 CCNB1，KIAA0101，UBE2C，RRM2，ORC1，POLA1，RFC5 Cellular component chromosome 0.023 CCNB1，HMGB2，HMGB3，ORC1，POLA1，RFC5 nucleoplasm 0.031 CCNB1，HMGB2，KIAA0101，UBE2C， DPP3，DKC1，ORC1，POLA1，DUT，RFC5 nuclear chromosome 0.0471 CCNB1，HMGB2，ORC1，POLA1 replication fork 0.0471 POLA1，RFC5 Molecular function four⁃way junction DNA binding 0.009 HMGB2， HMGB3 DNA binding, bending 0.0129 HMGB2， HMGB3 DNA polymerase activity 0.0178 DUT， DKC1， EIF1AX， HMGB2， HMGB3 KEGG pathways Pyrimidine metabolism 0.0027 RRM2，POLA1，DUT Porphyrin and chlorophyll metabolism 0.0064 HMBS，HCCS DNA replication 0.0064 POLA1，RFC5 Drug metabolism：other enzymes 0.0109 RRM2，DUT p53 signaling pathway 0.0109 CCNB1，RRM2 Cell cycle 0.0225 CCNB1，ORC1 Purine metabolism 0.0369 RRM2，POLA1