腺苷酸激酶催化产物释放过程中的水化动力学研究

孔剑阳,李文飞,王炜

Hydration process in the product releasing of the enzymatic cycle of Adenylate Kinase

Jianyang Kong,Wenfei Li,Wei Wang

图1 (a) AdK构象关闭状态的晶体结构(PDB code: 1AKE[18])；(b) AdK构象打开状态的晶体结构(PDB code: 4AKE[19])(c, d) AdK的两种可能的催化循环路径，路径(c)不涉及底物ATP与产物ADP共存的状态(ATP?ADP共存态)，路径(d)经由ATP?ADP共存态

Fig.1 LID domain is colored in red,NMP domain is colored in blue and core domain is colored in green.