Abstract: n-Caprylic acid esterification, with good reaction activity, is an important fine chemical products and has special application value in many fields such as synthetic cosmetics and pharmaceutical intermediates. The traditional process generally uses concentrated sulfuric acid as a catalyst, but there are many serious problems in the process, such as strong corrosiveness to the experimental apparatus, difficult recovery of the catalyst, environmental pollution, etc. Not in line with the current green, economical and sustainable development environment. But the strong acid macroporous cation exchange resin has many excellent features including high catalytic activity, high selectivity, good chemical stability, non-corrosiveness to equipment, no "three wastes" produce, and easy separation, so this article uses this catalyst. Through the amount of catalyst, the ratio of the reaction raw materials, the reaction temperature, the circulating flow in the intensified reactor, the number of catalyst re-use and other small test conditional optimization, as well as the thermodynamic and kinetic aspects of the esterification process, the research can be seen that the calculated value and experimental value is almost consistent. Thus on the industrial synthesis of n-caprylic acid esterification process has played a strong guiding role.