以毒性效应为先导的有毒物质鉴别研究

南京大学学报(自然科学版) ›› 2014, Vol. 50 ›› Issue (4): 414–.

以毒性效应为先导的有毒物质鉴别研究

郭婧,于红霞,王玉婷,史薇,邓东阳

出版日期:2014-08-22 发布日期:2014-08-22
作者简介: 污染控制与资源化研究国家重点实验室,南京大学环境学院,南京,210023
基金资助:
国家自然科学基金（21307054），江苏省自然科学基金（BK20130551），高等学校博士学科点专项科研基金（20130091120013），江苏省环境监测科研基金（1212），国家水体污染控制与治理重大专项（2012X07101-003）

Effect-directed analysis of key toxicants in complex mixtures: A review

Guo Jing, Shi Wei *, Yu Hongxia *, Deng Dongyang, Wang Yuting

Online:2014-08-22 Published:2014-08-22
About author: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China

摘要/Abstract

摘要： 环境污染通常是由多种污染物相互作用所共同引发的.通过单一的化学分析和生物检测手段很难全面检测环境样品中的主要污染组分,因而很难进行完善的环境风险评价.基于毒性效应的关键致毒物质鉴别方法(Effect-directedanalysis,EDA)旨在将环境效应与特定的化合物或结构对应起来,是一种有效鉴定环境效应与关键毒物的方法.该方法一般包括物理化学分离、化学分析和生物检测3个步骤.本文综述了EDA 发展历程及重大进步,分析比较了常用的物理化学分离方法和化学分析方法的适用范围、具体操作流程及优缺点,总结了结构筛选的方法及流程.在已有研究的调研基础上,针对最后的毒性确认步骤地提出了4种确认方法.本文同时指出了不能原位检测及难以避免毒性损失等EDA发展中的问题并分析了其今后的发展趋势.

Abstract: Since the sediment, water effluent and particulate matter is generally contaminated by a mix of complex compounds, it is hard to make an accurate hazard assessment by a chemical or biological analysis alone. As an advanced approach and an important tool in toxicity identification, the effect-directed analysis (EDA) links the effect data with certain compounds, and usually includes steps of physicochemical fractionation, chemical analysis and bio-testing. In this paper, the development of EDA and major progress are reviewed. The widely used approaches in the fractionation and chemical analysis were analyzed and compared, and also the procedure in structure elucidation was summarized and discussed. When realizing the toxicity confirmation in EDA approach had not been previously proposed, the paper also suggested four approaches for the finial confirmation in EDA. In addition, the importance of EDA application in actual environment rather than in the labs is highlighted.

郭婧,于红霞,王玉婷,史薇,邓东阳. 以毒性效应为先导的有毒物质鉴别研究[J]. 南京大学学报(自然科学版), 2014, 50(4): 414–.

Guo Jing, Shi Wei *, Yu Hongxia *, Deng Dongyang, Wang Yuting. Effect-directed analysis of key toxicants in complex mixtures: A review[J]. Journal of Nanjing University(Natural Sciences), 2014, 50(4): 414–.

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