Abstract: Chemical industrial wastewater treated by biochemical treatment is difficult to meet discharge standards due to its complex and refractory components. Thus advanced treatment of chemical industrial wastewater is important. Nonetheless, single treatment method after biochemical treatment is not sufficient. This work investigated the combination of optimized Fenton oxidation and magnetic hyper-crosslinked resin adsorption for the advanced treatment of the biochemical effluent of chemical industrial wastewater. Results showed that 62% of COD was removed after Fenton treatment under the optimized conditions (4 mmol/L FeSO4, 8 mmol/L H2O2 at pH 5 with the contact time of 90 min) for a biochemical effluent with the COD value of 145.5 mg/L. However, the dissolved organic matter in Fenton effluent is still at a high concentration. This Fenton effluent was better treated by hyper-crosslinked resin modified with anion exchange functional groups, which can be explained by the electrostatic interaction between resin and small molecular organic acid generated during Fenton oxidation. The removal rate of UV254 and COD were 53% and 59%, respectively by the optimized resin (GMA-5) with a strong base exchange capacity of 0.89 mmol/g and a specific surface area of 668 m2/g. GMA-5 could be reused with high adsorption capacity after regeneration. The combination of Fenton oxidation and magnetic resin adsorption was proved to be a feasible method for the advanced treatment of chemical industrial wastewater with removal rates of both UV254 and COD higher than 75%. The COD values after this combination method were lower than 40 mg/L.