南京大学学报(自然科学版) ›› 2010, Vol. 46 ›› Issue (5): 602–606.
• • 上一篇
蔡仁田, 沈玲** , 张永臣, 杨永峰
Cai Ren T ian, Shen Ling, Zhang Yong Chen, Yang Yong Feng
摘要： 通过观察慢性丙型肝炎( CHC)患者外周血 CD4 + T 细胞和 CD8 + T 细胞表面程序性死亡受体1( PD -1) 的表达水平以及与 HCV RNA 载量的关系, 推测其临床意义. 运用流式细胞仪检测外周血
CD4 + T 细胞和 CD8 + T 细胞表面 PD ?1 的表达, 荧光定量 PCR 检测 HCV RNA 载量, 基因芯片检测HCV 基因型. 结果显示, 外周血 CD4 + T 细胞和 CD8 + T 细胞表面 PD ?1 的表达, CHC 患者较健康人明
显上调, 不同 HCV 基因型之间表达没有差异, 与 HCV RNA 载量和 ALT 无相关性. 实验结果表明持续病毒血症可能是 PD ?1 在 CD4 + T 细胞和 CD8 + T 细胞表面的高表达的重要原因, PD?1 的表达水平差异
与 HCV 复制和肝细胞的破坏程度没有必然联系.
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